2. Signaling Pathways
  3. GPCR/G Protein
  4. Prostaglandin Receptor

Prostaglandin Receptor

Prostaglandin Receptor

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Prostaglandin receptor, a sub-family of cell surface seven-transmembrane receptors, are the G-protein-coupled receptors. There are currently ten known prostaglandin receptors on various cell types. Prostaglandins bind to a subfamily of cell surface seven-transmembrane receptors, G-protein-coupled receptors. These receptors are named: DP1-2-DP1, DP2 receptors, EP1-4-EP1, EP2, EP3, EP4 receptors, FP-FP, IP1-2-IP1, IP2 receptors, TP-TP receptor. The prostaglandins are a group of hormone-like lipid compounds that are derived enzymatically from fatty acids and have important functions in the animalbody. There are currently ten known prostaglandin receptors on various cell types.

Prostaglandin Receptor Isoform Specific Products:

Prostaglandin Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-135447
    BM-531
    		Inhibitor
    BM-531 is a dual-acting agent for thromboxane receptor (TXA2) antagonism and thromboxane synthase inhibition. BM-531 exerts anti-aggregatory effects on human citrated platelet-rich plasma (PRP), inhibiting Arachidonic acid (HY-109590A)-induced aggregation with an ED100 of 0.125 μM and U-46619 (HY-108566)-induced aggregation with an ED50 of 0.482 μM. BM-531 inhibits high-K+-induced contraction of porcine uterine smooth muscle.
    BM-531
  • HY-129934S
    Latanoprost ethyl amide-d4
    Latanoprost ethyl amide-d4 (Lat-NEt-d4) is deuterium labeled Latanoprost ethyl amide. Latanoprost ethyl amide (Lat-NEt) is a latanoprost analog in which the C-1 carboxyl group has been modified to an N-ethyl amide. Prostaglandin esters have been shown to have ocular hypotensive activity.1 Prostaglandin N-ethyl amides were recently introduced as alternative prostaglandin ocular hypotensive prodrugs. Although it has been claimed that prostaglandin ethyl amides are not converted to the free acids in vivo, studies in our laboratories have shown that bovine and human corneal tissue converts the N-ethyl amides of various prostaglandins to the free acids with a conversion rate of about 2.5 μg/g corneal tissue/hr. Lat-NEt would be expected to show the typical intraocular effects of Latanoprost free acid, but with the much slower hydrolysis pharmacokinetics of the prostaglandin N-amides.
    Latanoprost ethyl amide-d<sub>4</sub>
  • HY-143518
    TP-16
    TP-16 is a novel and selective EP4 antagonist with an IC50 of 2.1 nM.
    TP-16
  • HY-155321
    NXT-10796
    		Inhibitor
    NXT-10796 is orally active, intestinally restricted EP4 receptor agonist.
    NXT-10796
  • HY-112265
    CRTh2 antagonist 1
    		Antagonist
    CRTh2 antagonist 1 is a CRTh2 antagonist with an IC50 of 89 nM.
    CRTh2 antagonist 1
  • HY-14898
    AGN 210676
    		Agonist
    AGN 210676 is a selective prostaglandin EP2 agonist extracted from patent US20070203222A1, Compound example 23, has an EC50 of 5 nM.
    AGN 210676
  • HY-106110
    OP-2507
    OP-2507 is a prostacyclin analog. OP-2507 can increase brain glucose levels in mice, suppress the breakdown of energy metabolism under hypoxic conditions, and has a protective effect against changes in cyclic nucleotides in hypoxic brain tissue (specifically, an increase in cyclic AMP and a decrease in cyclic GMP). OP-2507 provides protective effects against brain hypoxia and edema.
    OP-2507
  • HY-B0428D
    (E/Z)-Ozagrel sodium
    (E/Z)-Ozagrel sodium [(E/Z)-OKY-046 sodium] is an EZ configuration mixture of Ozagrel sodium (HY-B0428A). Ozagrel sodium (OKY-046 sodium) is a high selective and orally active thromboxane A2 (TXA2) synthase inhibitor with an IC50 of 11 nM. Ozagrel sodium exerts anti-platelet aggregation, vasodilation and anti-inflammatory effects by inhibiting the production of TXA2 and increasing the production of prostacyclin (PGI2). Ozagrel sodium can be used for the study of ischemic stroke, asthma and thromboembolic diseases.
    (E/Z)-Ozagrel sodium
  • HY-118014
    CAY10535
    		Inhibitor
    CAY10535 is a FP and TP receptor inhibitor and can be used for research of cardiovascular diseases.
    CAY10535
  • HY-126084
    Carbaprostacyclin methyl ester
    Carbaprostacyclin methyl ester is a methylated derivative of Carbacyclin (HY-112322).
    Carbaprostacyclin methyl ester
  • HY-106398
    MED 27
    MED 27 is an inhibitor of thromboxane synthase and thromboxane A2 receptors. MED 27 can inhibit rat platelet aggregation at doses much lower than that of acetylsalicylic acid (HY-14654).
    MED 27
  • HY-114947
    9-deoxy-9-methylene Prostaglandin E2
    9-deoxy-9-methylene Prostaglandin E2 (9-deoxy-9-methylene PGE2) is a stable, isosteric analog of PGE2. 9-deoxy-9-methylene PGE2 retains the biological profile of PGE2 with fewer side effects. In the rat 9-deoxy-9-methylene PGE2 is equipotent to PGE2 in decreasing blood pressure. It also stimulates the gerbil colon and primate uterus at the same potency as PGE2.
    9-deoxy-9-methylene Prostaglandin E2
  • HY-114761
    Prostaglandin F2α dimethyl amine
    		Antagonist
    Prostaglandin F2α dimethyl amine is a Prostaglandin F2α (HY-12956) derivative. Prostaglandin F2α dimethyl amine is an antagonist for Prostaglandin F receptor (FP). Prostaglandin F2α dimethyl amine blocks the cardiovascular responses induced by orexin and Arachidonic acid (HY-109590).
    Prostaglandin F2α dimethyl amine
  • HY-137567
    Prostaglandin E1 ethanolamide
    		Activator
    Prostaglandin E1 ethanolamide is an analog of prostaglandin E1 (PGE1) and may effectively inhibit GLI2-induced expression of target genes, including Gli1 and Ptch1, and tumor growth.
    Prostaglandin E1 ethanolamide
  • HY-126986
    Tetranor-PGDM
    Tetranor-PGDM is an abundant urinary metabolite reflects biosynthesis of prostaglandin D2.
    Tetranor-PGDM
  • HY-123400A
    iso-Samixogrel
    		Inhibitor
    Iso-Samixogrel (iso-DTTX30) is a combined thromboxane A2 receptor blocker and thromboxane synthetase inhibitor that exhibits potent antithrombotic activity. Iso-Samixogrel effectively eliminates recurrent arterial thrombus formation and inhibits collagen-induced platelet aggregation ex vivo. Iso-Samixogrel also prolongs sublingual bleeding time, demonstrating its biological efficacy in managing thrombosis.
    iso-Samixogrel
  • HY-129293
    AFP-07 free acid
    		Agonist
    AFP-07 free acid is a derivative of 7, 7-difluoroprostacyclic and is a highly potent and selective prostacyclin receptor IP receptor agonist with a Ki value of 0.561 nM.
    AFP-07 free acid
  • HY-137504
    20-ethyl Prostaglandin F2α
    20-ethyl Prostaglandin F2α (ICI 74205; 20-ethyl PGF2α) is an analog of PGF2α and an arachidonic acid (HY-109590) metabolite.
    20-ethyl Prostaglandin F2α
  • HY-123112
    Hoe 892
    Hoe 892 (S792892A) is an orally active prostacyclin derivative with antiplatelet aggregation and vasodilatory activity. Hoe 892 can be used in the study of cardiovascular diseases such as thrombosis.
    Hoe 892
  • HY-P1813
    PSA1 (141-150)
    PSA1 (141-150), a prostate specific antigen 1 peptide, is used in the immunotherapy of cancer experiments.
    PSA1 (141-150)
Cat. No. Product Name / Synonyms Application Reactivity
Prostaglandin Receptor Isoform Comparison

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